RiteMED Vitamin B-Complex + Iron + Buclizine HCl Overdosage

Vitamins B₁ and B₁₂ are known to be generally safe in humans when taken at recommended doses.
Buclizine Hydrochloride: In general, symptoms of overdosage with the use of antihistamines such as buclizine hydrochloride are similar to atropine overdosage. These include dilated pupils, abnormal eye movements, flushed face, dry mouth, urinary retention, fever, excitation, disorientation, hallucinations, etc. Central nervous system depression with drowsiness or coma which may be followed by excitement, seizures, and finally depression have also been reported.
Treatment consists mainly of supportive care and rapid gastric emptying. Convulsions can be controlled with diazepam. Anticholinergic symptoms can be managed with neostigmine and physostigmine.
Pyridoxine Hydrochloride (Vitamin B₆): Long term (i.e., 2 months or longer) administration of large (megadose) dosages (e.g., usually 2 g or more daily) of pyridoxine can cause sensory neuropathy or neuronopathy syndromes. Peripheral sensory neuropathy has been reported in individuals receiving pyridoxine dosages of 1 to 4 g daily. Adverse neurologic effects have also been reported rarely following chronic administration of lower dosages (e.g., 500 mg daily) of pyridoxine. Following discontinuance of pyridoxine, neurologic dysfunction gradually improved, and following a prolonged follow-up period, the patients were reported to recover satisfactorily.
Iron (as Ferrous Fumarate): Symptoms of acute iron overdosage can be divided into four stages: Stage I: Occurs up to six hours after ingestion - the principal symptoms are vomiting and diarrhea; other symptoms include hypertension, tachycardia and central nervous system depression ranging from lethargy to coma.
Stage II: May occur 6 to 24 hours after ingestion and is characterized by a temporary remission or signs of overdosage are decreased.
Stage III: Gastrointestinal symptoms recur accompanied by shock, metabolic acidosis, coma, liver necrosis, jaundice, hypoglycemia, kidney failure, and pulmonary edema.
Stage IV: Occur several weeks after ingestion and is characterized by gastrointestinal obstruction and liver damage.
Gastric lavage with 1% sodium bicarbonate or induction of vomiting should be undertaken. Deferoxamine has also been used as additive to gastric lavage solutions to chelate elemental iron in the gastrointestinal tract.
Supportive treatment such as suction and maintenance of airway, correction of acidosis, and control of shock and dehydration should be administered as required when a potentially lethal dose of iron (e.g., 5,400-10,000 mg elemental iron per day) has been ingested.